INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) CORRECTED VERSION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 1111111111110110101011111011010 I 0111 10111111111001101110111 10# (10) International Publication Number WO 2018/187630 A8 11 October 2018 (11.10.2018) WIPO I PCT (51) International Patent Classification: A61K 31/4745 (2006.01) CO7D 471/10 (2006.01) CO7D 471/04 (2006.01) (21) International Application Number: PCT/US2018/026339 (22) International Filing Date: 05 April 2018 (05.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/481,981 05 April 2017 (05.04.2017) US MA INC. [US/US]； 225 Binney Street, Cambridge, MA 02142 (US). (72) Inventors: WAGNER, Florence, Fevrier； 4 Old Coun- try Path, Ashland, MA 01721 (US). WEIWER, Michel； 18 Hunting Street, Apt 1, Cambridge, MA 02141 (US). CAMPBELL, Arthur, J； 189 Lexington Avenue, Cam- bridge, MA 02138 (US). SACHER, Joshua, R.； 40 Marion Street, Somerville, MA 02143 (US). HOLSON, Edward； 66 Forest Street, Newton, MA 02461 (US). LUCAS, Bri- an, Stuart； 4 Brantwood Road, Arlington, MA 02476 (US). CHEN, TeYu； 8 Brighton Street Unit 1, Charlestown, MA 02129 (US). Agent: ZHANG, Wei； Wolf, Greenfield & Sacks, P.C., 600 Atlantic Avenue, Boston, MA 02210-2206 (US). (74) (71) Applicants: THE BROAD INSTITUTE, INC. [US/US]； 415 Main Street, Cambridge, MA 02142 (US). BIOGEN (54) Title: TRICYCLIC COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK3) INHIBITORS AND USES THEREOF FIG.3 (1) GC O er) N GC 1-1 00 O 1-1 N O (57) : The present disclosure provides compounds of Formula (I), and salts, solvates, hydrates, polymorphs, co-crystals, tau- tomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided compounds may be useful for inhibiting kinases, e.g., glycogen synthase kinase 3 (GSK3). The provided compounds may be able to selectively inhibit GSK3a, as compared to GSK3P and
