The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human EGFR. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.本發明係關於抗原結合分子(ABMs)。在特定實施例中，本發明係關於對人類EGFR具有特異性之重組性單株抗體，其包括嵌合、靈長類化或人類化抗體。此外，本發明係關於編碼該等ABMs之核酸分子及包含該等核酸分子之載體及宿主細胞。本發明進一步係關於製備本發明ABMs的方法及使用該等ABMs來治療疾病的方法。此外，本發明係關於經修釋糖基化而具有改良治療性質的ABMs，其包括具有增加之Fc受體結合性及增加之效應功能的抗體。
