This invention concerns a method for sealing dentinal tubules exposed at the tooth surface as a consequence of enamel defects, based on amorphous calcium polyphosphate microparticles that, in contrast to polyphosphate-calcium salts/complexes, strongly bind both to tooth enamel, cementum and dentin surfaces. The inventive method uses microsized particles, consisting a biocompatible and biodegradable polymer (calcium polyphosphate), can be applied not only for protective teeth coatings but also in the fabrication of morphogenetically- active tooth implants that stimulate differentiation of precursor odontoblasts to mature, alkaline phosphatase-expressing cells, with a hardness and elastic modulus close to natural enamel. The invention furthermore relates to an improved biomimetic dental composition, in particular a toothpaste, containing the morphogenetically active amorphous polyphosphate (polyP) microparticles enriched with retinyl acetate. The inventive composition efficiently repairs both cracks/fissures and carious lesions in the tooth enamel, and reseals dentinal tubules, already after a short-time treatment of teeth. Moreover, this composition significantly increases the growth of human mesenchymal stem cells and the expression of marker genes for osteoblast differentiation. A further aspect of this invention then concerns the finding that the polyP ingredient, supplied as zinc-polyP microparticles strongly inhibits the growth of the cariogenic bacterium Streptococcus mutans. The inventive composition is particularly suitable for a prevention/repair of (cariogenic) damages of tooth enamel/dentin and for the treatment and/or prevention of dental hypersensitivity.La présente invention concerne un procédé permettant de sceller des tubules dentinaires exposés au niveau de la surface des dents en conséquence de défauts de l'émail, sur la base de microparticules de polyphosphate de calcium amorphe qui se lient solidement à la fois à l'émail, au cément et aux surfaces
