Inhibitor of breton-type tyrosine kinase

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专利权人:

エフ．ホフマン－ラ;アーゲー;ロシュ;エフ.ホフマン-ラ ロシュ アーゲー

发明人:

ドミニク，ロミヤー,コン，ノーマン,ロウ，イェン,ロペス－タピア，フランシスコ・ハビアー,ソ，スン－ソウ,ドミニク,ロミヤー,コン,ノーマン,ロウ,イェン,ロペス-タピア,フランシスコ・ハビアー,ソ,スン-ソウ

申请号：

JP2016539189

公开号：

JP6294490B2

申请日:

2014.12.10

申请国别(地区):

JP

年份:

2018

代理人:

摘要：

This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

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