Provided are a transdermal absorption sheet capable of suppressing a sheet portion from being curled and of improving impact resistance of the sheet portion, and a method of manufacturing the transdermal absorption sheet, capable of suppressing a sheet portion from being curled in drying and of shortening a time required for drying a base material liquid. A transdermal absorption sheet 10 includes: a sheet portion 14； a plurality of needle-like protruding portions 12 that are arranged on one surface of the sheet portion 14； and a sheet-like mesh structure body 16 that is included in the sheet portion 14 and that has an area, in a plan view, including at least a part of a region S in which the plurality of needle-like protruding portions 12 are arranged.
