The present invention discloses a novel synergistic topical wound healing composition comprising of therapeutically effective amount of amnion, therapeutically effective amount of Aloe vera gel, therapeutically effective amount of curcumin and therapeutically effective amount of at least one matrix metalloproteinase inhibitor. The composition further includes at least one antimicrobial agent, at least one antioxidant, at least one preservative, and at least one stabilizing agent. The components of the composition are being present therein in a proportion producing a synergistic activity with regard to the wound healing property conferred. The composition can completely cover the wound area and is used in treating various types of wounds and ulcers of mammalian skin.
