Karolina A. Hosiawa;Andrew J. Murphy;Sean Stevens;Lynn Macdonald;Cagan Gurer
发明人:
Lynn Macdonald,Sean Stevens,Cagan Gurer,Andrew J. Murphy,Karolina A. Hosiawa
申请号：
US13166171
公开号：
US09012717B2
申请日:
2011.06.22
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice that express hVλ sequences from a transgene or an episome wherein the hVλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins. Compositions and methods for making antigen-binding proteins that comprise human λ variable sequences, including human antibodies, are provided.
