PROBLEM TO BE SOLVED: To provide a medical tube seal device set capable of smoothly performing seal welding even for a tube with folding deformation, etc. and suppressing an occurrence of a sealing failure.SOLUTION: A medical tube seal device set 1 includes a plurality of tube seal devices 10A-10H. The plurality of tube seal devices 10A-10H include tube seal parts 20A-20H arranged at the front of the devices respectively, elevating and lowering mechanisms for elevating and lowering the tube seal parts 20A-20H along a vertical axis, and control parts for at least controlling the elevating and lowering operation of the tube seal parts 20A-20H by the elevating and lowering mechanisms.SELECTED DRAWING: Figure 1