COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION;THE STATE OF NEW SOUTH WALES THROUGH ITS DEPARTMENT OF AGRICULTURE;THE STATE OF QUEENSLAND THROUGH ITS DEPARTMENT OFPRIMARY INDUSTRIES;THE
发明人:
ADRIAN LESLIE MARK HODGSON,CHRISTOPHER THOMAS PRIDEAUX
申请号：
BR9611278
公开号：
BR9611278B1
申请日:
1996.11.01
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
<；b>； pasteurella haemolytica leukotoxin immunity <；d>；. Bovine respiratory disease complex (BRD), embarkation fever, or pasteurellosis pneumonia, is a multifactorial disease so a combination of viral infection, adverse environment, and poor immune status can combine to predispose animals to bacterial infection. Exotoxin, or leukotoxin (lkt), may contribute to pathogenesis by impairing the lungs main defenses and subsequent immune responses or causing inflammation resulting from leukocyte lysis. The present invention provides a modified microorganism that produces a lkt toxin, wherein said lkt toxin is partially or totally inactivated. In a further embodiment of the present invention there is provided a modified microorganism wherein a lkt toxin operon including a lkt structural gene and / or an organism post-translational activator is partially or totally inactivated. present depositors have found that a lkt toxin precursor has reduced toxic activity. surprisingly, the lkt toxin precursor is capable of inducing an immune response in a material that offers cross-protection against heterologous challenge with a lkt toxin producing microorganism. a microorganism that naturally produces a lkt toxin can be constructed to produce an inactive lkt toxin precursor by eliminating the post-translatory activator of the precursor product. therefore, in a preferred embodiment the microorganism is unable to produce a post-translational activator of the lkt toxin precursor or produces an inactivated post-translational activator of the lkt toxin precursor. the post-translational activator may be a c lkt gene product.<；b>；imunidade contra leucotoxina de pasteurella haemolytica <；d>；. complexo de doença respiratória bovina (brd), febre do embarque, ou pasteurelose pneumônia, é uma doença multifatorial pelo que uma combinação de infecção viral, ambiente adverso e status imune deficiente podem combinar para predispor animais a infecção bacterianas. a exotoxina, ou leuco
