RURAL DEVELOPMENT ADMINISTRATION);대한민국(농촌진흥청장);REPUBLIC OF KOREA(MANAGEMENT
发明人:
안미영,황재삼,윤형주,윤은영,김순자,김반지,AHN, MI YOUNGKR,HWANG, JAE SAMKR,YOON, HYUNG JOOKR,YUN, EUN YOUNGKR,KIM, SUN JAKR,KIM, BAN JIKR
申请号：
KR1020170081156
公开号：
KR1020170080555A
申请日:
2017.06.27
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
Glucosaminoglycan derived from queen bee bumblebees inhibits accumulation of abdominal fat in the body during high fat diet, reduces cholesterol content and reduces free fatty acids in serum. Prolonged plasma partial thromboplastin time (APTT) in the plasma prevents platelet aggregation and inhibits adhesion protein-related laminin present in the vascular endothelium. It also inhibits protein damage to blood globulin and inhibits lipid peroxide accumulation (MDA levels) in hepatocytes. In addition, at the cellular level, NO (nitric oxide) is generated in vascular endothelial cells to relax blood vessels. In addition, it was confirmed that the increase of blood pressure was prevented by the high fat diet after the administration of the rat for one month. Glucozaminoglycan derived from queen bee bumblebee provides a composition for inhibiting lipid accumulation, inhibiting adhesion of cell membrane adhesive protein, lowering blood pressure, and preventing thrombosis.호박벌여왕벌 유래 글라이코자미노글라이칸은 고지방 식이 시 체내 복부지방 축적을 억제하며 콜레스테롤 함량을 감소시키며 혈청내 유리지방산을 감소시킨다. 혈장 내 APTT(activated partial thromboplastine time, 활성된 부분 트롬보프라스틴 시간)을 연장하여 혈액응고를 방지하며 혈관내피에 존재하는 접착단백질관련 라미닌을 억제한다. 또한 혈중 글로블린의 단백손상을 억제하고 간세포의 과산화지질 축적(MDA 양)을 억제한다. 또한 세포수준에서 볼 때, 혈관내피세포에서 NO(산화질소)를 발생시켜 혈관이완시킨다. 더불어 랫트 한 달 투여 후 고지방식이에 의한 혈압상승을 방지함을 확인할 수 있었다. 호박벌여왕벌 유래 글라이코자미노글라이칸은 지질축적 억제, 세포막접착성단백질 부착억제, 혈압강하, 혈전예방의 용도 조성물을 제공한다.
