The present invention relates to a pharmaceutical composition for preventing or treating muscle hypoxia comprising the extract of Beecha leaf as an active ingredient, wherein the extract of Beecha leaf reduces the amount of creatine kinase induced by dexamethasone administration, It was confirmed that the damage was reduced. It was also found that muscle hypoxia was greatly influenced by the degradation of MyHC by MuRF1, which is regulated by FoxO1, and that administration of Becker leaf extract decreases muscle degradation in dexamethasone-induced muscle hypoxia By confirming, it was suggested that the extract of Beech leaf can be used as a therapeutic agent for hypersensitivity.본 발명은 비파잎 추출물을 유효성분으로 함유하는 근육 감소증 예방 또는 치료용 약학조성물에 관한 것으로, 비파잎 추출물이 덱사메타손(dexamethasone) 투여에 의해 유도된 크레아틴 키나제(creatine kinase)량을 감소시키고, 근육의 손상을 감소시킨 것을 확인하였다. 또한, 근육 감소증은 FoxO1에 의해 조절 받는 MuRF1에 의한 MyHC의 분해에 매우 큰 영향을 받는 것을 알 수 있었는데, 비파잎 추출물의 투여는 덱사메타손(dexamethasone)으로 유도된 근육 감소증에 있어서 근육분해를 감소시킨다는 것을 확인함으로써, 비파잎 추출물이 근육 감소증 치료제로서 이용될 수 있다는 가능성이 시사되었다.
