Pascal André Stein;Gordon D. Webster;Kin-Ming Lo;Suzanne P. McKenzie
发明人:
Gordon D. Webster,Suzanne P. McKenzie,Kin-Ming Lo,Pascal André Stein
申请号：
US13478897
公开号：
US20130034518A1
申请日:
2012.05.23
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and Arg261. The modified IL-12p40 polypeptides according to the invention have improved stability compared to wild-type mature human IL-12p40 polypeptides.
