Novel Ajoene derivatives preparation method thereof and pharmaceutical composition for use in preventing or treating cancer containing the same as an active ingredient
SOOKMYUNG WOMEN′S UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION;SOOKMYUNG WOMEN'S UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION;숙명여자대학교산학협력단
发明人:
JEON, RA OK,전라옥,RYU, JAE HA,류재하,CHO, HYE WON,조혜원,JEON, RA OKKR,RYU, JAE HAKR,CHO, HYE WONKR
申请号：
KR1020170090473
公开号：
KR1020180008350A
申请日:
2017.07.17
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to novel ajoene derivatives, to a preparation method thereof, and to a pharmaceutical composition for preventing or treating cancer containing the same as active ingredients, wherein the novel ajoene derivatives according to the present invention were confirmed to inhibit proliferation of human renal cancer cell line (ACHN), breast cancer cell line (MDA-MB-231), colorectal cancer cell line (HCT-15), prostate cancer cell line (PC-3), stomach cancer cell line (NUGC-3) and lung cancer cell line (NCI-H23) to be usefully used as a pharmaceutical composition for preventing or treating cancer containing the same as the active ingredients.본 발명은 신규한 아조엔 유도체, 이의 제조방법 및 이를 유효 성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 신규한 아조엔 유도체는 신장암 세포주(ACHN), 유방암 세포주(MDA-MB-231), 대장암 세포주(HCT-15), 전립선암 세포주(PC-3), 위암 세포주(NUGC-3), 및 폐암 세포주(NCI-H23)의 증식을 억제할 수 있는 것으로 확인되어, 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물로 유용하게 사용될 수 있다.
