Compositions and methods for treating macular degeneration are disclosed. The methods utilize gene delivery to human eyes of soluble Flt-1 receptors, 5 as well as fusion proteins including a soluble Flt-1 receptor.本發明係揭示用於治療黃斑部病變之組成物和方法。此方法係利用基因遞送可溶性Flt-1受體,以及包括可溶性Flt-1受體之融合蛋白至人類眼睛。