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Attenuated Bordetella Strains
专利权人:
Institut Pasteur de Lille;Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人:
Camille Locht,Nathalie Mielcarek,Anne-Sophie Debrie,Dominique Raze,Julie Bertout
申请号:
US16787767
公开号:
US20200171139A1
申请日:
2020.02.11
申请国别(地区):
US
年份:
2020
代理人:
摘要:
A mutated Bordetella strain comprising at least a mutated ptx gene, a deleted or mutated dnt gene and a heterologous ampG gene is provided. The attenuated mutated Bordetella strain can be used in an immunogenic composition or a vaccine for the treatment or prevention of a Bordetella infection. Use of the attenuated Bordetella strain for the manufacture of a vaccine or immunogenic composition, as well as methods for protecting mammals against infection by Bordetella are also provided.
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