Methods are described for preventing or reducing cytoskeletal rearrangement and intercellular gap formation by contacting cells with an aminoalkyl glucosaminide phosphate. In particular, the disclosed methods can be used to prevent or reduce actin cytoskeletal rearrangement and/or intracellular gap formation related to ischemic or ischemia-reperfusion events and to prevent or alleviate diseases or conditions related to increased actin cytoskeletal rearrangement.
