Silvia S. Jurisson,Cathy S. Cutler,Anthony J. Degraffenreid
申请号：
US14679520
公开号：
US09427483B2
申请日:
2015.04.06
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention is directed to a series of stable radioisotope trithiol complexes that provide a simplified route for the direct complexation of radioisotopes present in low concentrations. In certain embodiments, the complex contains a linking domain configured to conjugate the radioisotope trithiol complex to a targeting vector. The invention is also directed to a novel method of linking the radioisotope to a trithiol compound to form the radioisotope trithiol complex. The inventive radioisotope trithiol complexes may be utilized for a variety of applications, including diagnostics and/or treatment in nuclear medicine.
