COMBINATION THERAPY WITH A PHOSPHOINOSITIDE 3-KINASE INHIBITOR WITH A ZINC BINDING MOIETY

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专利权人:

Curis; Inc.

发明人:

Fattaey, Ali,Rhyasen, Garrett W.

申请号：

AU2020227036

公开号：

AU2020227036A1

申请日:

2020.09.02

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

#$%^&*AU2020227036A120200917.pdf#####ABSTRACT The invention provides a method of treating cancer in a subject in need thereof, comprising administering to the subject: (a) a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R is hydrogen or an acyl group； and (b) a BCL-2 inhibitor； wherein the compound of Formula I or pharmaceutically acceptable salt thereof and a BCL-2 inhibitor are administered in amounts which in combination are therapeutically effective. The invention further provides a pharmaceutical composition comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, a BCL-2 inhibitor and a pharmaceutically acceptable carrier or excipient.

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