the invention relates to derivatives of 1,2,4-triazole - 3 - tionu of general formula 1, where r means a group: etylow\u0105, butyl, pentylow\u0105, heksylow\u0105, heptylow\u0105, oktylow\u0105, nonylow\u0105 and their farmaceutycznie acceptable salts and their use for the treatment of tonic clonic seizures and the seizures part iowych secondary or without secondary generalisation.process for the production of derivatives of l, 2,4 - triazolo - 3 - tionu of general formula 1 is that maleic 3 - chlorofenylooctowego undergo reaction with the appropriate izotiocyjanianem, whereby the reaction is in a mole ratio of 1: 1, in the foot, or in polar solvents, or rozpuszcz alnikach not polar.in the case of a reaction mixture in a substrate heated at 100 - 140\u00b0c by 1 - 5 minutes, and in the case of the reaction in polar solvent environment especially ethyl alcohol process leads in boiling point solvent for a period of 5 - 30 minutes t.in contrast, reaction in a solvent not polar especially diethyl ether process runs for 12 to 36 hours at room temperature, then after cooling, formed product of equation 4 ods\u0105cza and crystallizes with a suitable solvent polar, preferably with et anolu and received a tiosemikarbazydu undergo reaction cyklizacji in aqueous hydroxide solution.after the solution is an aqueous solution of hydrochloric acid to obtain a reaction, preferably an acidic, and the precipitated compound model 1, crystallizes with a suitable solvent polar, preferably with ethanol.Wynalazek dotyczy pochodnych 1,2,4-triazol-3-tionu o wzorze ogólnym 1, gdzie R oznacza grupę: etylową, butylową, pentylową, heksylową, heptylową, oktylową, nonylową i ich farmaceutycznie dopuszczalne sole oraz ich zastosowania do leczenia napadów toniczno-klonicznych oraz napadów częściowych z wtórnym lub bez wtórnego uogólnienia. Sposób wytwarzania pochodnych l,2,4-triazolo-3-tionu o wzorze ogólnym 1 polega na tym, że hydrazyd kwasu 3-chlorofenylooctowego poddaje się reakcji z odpowiedni
