Jay Copeland Strum,John E. Bisi,Patrick Joseph Roberts,Jessica A. Sorrentino
申请号:
US16572418
公开号:
US20200022983A1
申请日:
2019.09.16
申请国别(地区):
US
年份:
2020
代理人:
摘要:
This invention is in the area of improved therapeutic combinations for and methods of treating selected retinoblastoma (Rb)-negative cancers and Rb-negative abnormal cellular proliferative disorders using particular topoisomerase inhibitors and specific cyclin-dependent kinase 4/6 (CDK4/6) inhibitors. In one aspect, the improved treatment of select Rb-negative cancers is disclosed using specific compounds disclosed herein in combination with a topoisomerase I inhibitor.