The 1,2,3,4- tetrahydro cyclopentyl being substituted of autoimmune disease and inflammatory disease simultaneously [b] indol-3-yl acetogenin can be treated with what农业专利-农业学术服务平台

专利权人:: 艾尼納製藥公司;Arena Pharmaceuticals; Inc.;Arena Pharmaceuticals, Inc.;艾尼纳制药公司

发明人:: 罗伯特．M．琼斯,羅伯特．M．瓊斯,丹尼尔．J．布扎德,丹尼爾．J．布扎德,韩相敦,韓相敦,金善姬,朱尔格．莱曼,朱爾格．萊曼,布雷特．厄尔曼,布雷特．厄爾曼,珍妮．V．穆迪,朱秀文,斯科特．斯特恩,罗伯特.M.琼斯,羅伯特.M.瓊斯,丹尼尔.J.布扎德,丹尼爾.J.布扎德,朱尔格.莱曼,朱爾格.萊曼,布雷特.厄尔曼,布雷特.厄爾曼,珍妮.V.穆迪,斯科特.斯特恩

摘要：: The present invention relates to 1 be substituted of certain formulas (Ia), 2,3,4- tetrahydro cyclopentyls simultaneously [b] indol-3-yl acetogenin and its pharmaceutical salts, the pharmacological property to show one's usefulness, such as S1P1 receptor stimulating agent. The present invention also provides the pharmaceutical composition containing the compounds of this invention and using the method for the compounds of this invention and composition treatment S1P1 receptor related disorder, the S1P1 receptor related disorder is such as psoriasis, rheumatoid arthritis, Crohn disease, graft rejection, multiple sclerosis, systemic loupus erythematosus, ulcerative colitis, type-1 diabetes mellitus, acne, microorganism infection or microbial diseases and virus infection or virus disease.本發明涉及某些式(Ia)的經取代的1,2,3,4-四氫環戊并[b]吲哚-3-基乙酸衍生物及其藥用鹽，其顯示出有用的藥理學性質，例如作爲S1P1受體激動劑。本發明還提供了含有本發明化合物的藥物組合物及使用本發明化合物和組合物治療S1P1受體相關障礙的方法，所述S1P1受體相關障礙爲例如牛皮癬、類風濕性關節炎、克羅恩病、移植物排斥、多發性硬化、系統性紅斑狼瘡、潰瘍性結腸炎、I型糖尿病、痤瘡、微生物感染或微生物疾病及病毒感染或病毒疾病。