ZITVOGEL, Laurence,YAMAZAKI, Takahiro,REKDAL, Øystein,SVEINBJØRNSSON, Baldur,SVENDSEN, John Sigurd Mjøen,CAMILIO, Ketil,EIKE, Liv Marie
申请号：
DK15793746
公开号：
DK3230318T3
申请日:
2015.11.04
申请国别(地区):
DK
年份:
2020
代理人:
摘要：
The present invention provides a compound, preferably a peptide, having the following characteristics: a) consisting of 9 amino acids in a linear arrangement； b) of those 9 amino acids, 5 are cationic and 4 have a lipophilic R group； c) at least one of said 9 amino acids is a non-genetically coded amino acid (e.g. a modified derivative of a genetically coded amino acid)； and optionally d) the lipophilic and cationic residues are arranged such that there are no more than two of either type of residue adjacent to one another； and further optionally e) the molecule comprises two pairs of adjacent cationic amino acids and one or two pairs of adjacent lipophilic residues； for use in the treatment of a tumour by combined, sequential or separate administration with an immune checkpoint inhibitor. The present invention further provides pharmaceutical packs or compositions comprising these active agents and methods of treating a tumour comprising administration of these active agents. Also provided are the peptidic compounds as defined above for use in the destabilisation of a mitochondrial membrane, and a peptidic compound as defined above and an immunotherapeutic agent as a combined preparation for separate, simultaneous or sequential use in treating tumours.
