The present invention provides imidazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof.These compounds are useful in the treatment of RAGE-mediated diseases such as Alzheimers Disease.The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use the such compounds and/or pharmaceutical compositions in treating RAGE-mediated diseases.本發明提供式(I)之咪唑衍生物及其醫藥上可接受之鹽。該等化合物可用於治療RAGE介導疾病,例如阿茲海默氏病(Alzheimers Disease)。本發明另外係關於製備式(I)化合物及其醫藥上可接受之鹽之方法、包含該等化合物之醫藥組合物、及該等化合物及/或醫藥組合物在治療RAGE介導疾病中之用途。