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GRANULES CONTAINING BITTER DRUG AND ORALLY DISINTEGRATING TABLET
专利权人:
KYOWA HAKKO KIRIN CO.; LTD.
发明人:
MIYAMOTO, YUJI,TOKUDA, TAKUYA,OTA, MOTOHIRO,ISHIKAWA, YASUHIRO
申请号:
EP11821366
公开号:
EP2614816A4
申请日:
2011.04.08
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
It is an object of the present invention to provide a powder, a granule, an orally-disintegrating tablet, and the like that contain a drug causing bitterness, and that can suppress the bitterness in the mouth and improve solubility thereof in the stomach. The present invention provides a drug-containing granule comprising (a) a core particle that contains a drug causing bitterness, and (b) a masking coating that coats the core particle,wherein the masking coating contains:at least one polymer selected from methacrylic acid copolymer S, methacrylic acid copolymer L, methacrylic acid-ethyl acrylate copolymer, ethyl acrylate-methyl methacrylate copolymer, and ethyl acrylate-methyl methacrylate-ethyl ammonium trimethyl chloride methacrylate copolymer andat least one diluent selected from D-mannitol, lactose, trehalose, xylitol, maltitol, and erythritol,an orally-disintegrating tablet comprising the drug-containing granule, and the like.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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