Rudolph Volkmer;Lars Vouilleme;Dean R. Madden;Patrick R. Cushing;Prisca Boisguearin
发明人:
Dean R. Madden,Patrick R. Cushing,Prisca Boisguearin,Rudolph Volkmer,Lars Vouilleme
申请号：
US13292151
公开号：
US20120071396A1
申请日:
2011.11.09
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.
