BEN-MOSHE, Tehila,CARR, Francis Joseph,HOLGATE, Robert George E.,JONES, Timothy David,SCHACHTER, Jacob,MARKEL, Gal,ORTENBERG, Rona,SAPIR, Yair,MANDEL, Ilana
申请号:
PE0021392016
公开号:
PE07642017A1
申请日:
2015.04.27
申请国别(地区):
PE
年份:
2017
代理人:
摘要:
Humanized Antibodies are provided, capable of specific Binding to Human moleculass of CEACAM1 Restorative containing mutations of human in different murine variable regions of cor and polynucleotide Coding sequences Pharmaceutical compositions are also provided. S comprising these Antibodies.As well as the methods of their use to treat Cancer and other conditions and diagnoseSe proporcionan anticuerpos humanizados, capaces de union especifica a moleculass de CEACAM1 humana que contienen mutaciones restauradoras de humano a murino en regiones variables distintas de CDR, y sus secuencias codificadoras de polinucleotidos tambien se proporcionan composiciones farmaceuticas que comprenden estos anticuerpos, asi como sus metodos de su uso para tratar y diagnosticar cancer y otras condiciones