Disclosed herein is a topical treatment regimen including a prostaglandin F2α analog and a topical steroid for treating skin conditions, including skin pigmentation disorders associated with hypopigmentation such as vitiligo and nonfacial vitiligo. Examples of prostaglandin F2α analogs include bimatoprost, carboprost, dinoprost, fluprostenol, latanoprost, prostamide F2α, tafluprost, travoprost, and unoprostone, with bimatoprost being preferred. Examples of topical steroids include aclometasone, betamethasone, clobetasol, clobetasone, diflucortolone, fluocinolone, fluprednidene, flurandrenolide, fluticasone, halometasone, hydrocortisone, methylprednisolone, mometasone, prednicarbate, and triamcinolone, with mometasone being preferred. The topical treatment regimen includes one or more topical compositions, with the prostaglandin F2α analog and the topical steroid being contained either in separate topical compositions or in the same topical composition.
