CHRISTINE HIU-TUNG CHEN,NOEL CHIN CHIN,LUCIAN V. DIPIETRO,JIANME FAN,MARK G. PALERMO,MICHAEL DAVID SHULTZ,BAKARY-BARRY TOURE
申请号：
MX2014000536
公开号：
MX2014000536A
申请日:
2012.07.13
申请国别(地区):
MX
年份:
2014
代理人:
摘要：
The present invention provides for compounds of formula (I).The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer. The present invention provides for compounds of formula (I).The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer. There is provided a compound which is (a) a pyrimidine sulfonamide of formula (I) or (b) a pharmaceutically acceptable salt thereof, crystalline forms of the compound, processes for obtaining the compound, pharmaceutical intermediates used in the manufacture of the compound, and pharmaceutical compositions containing the compound. The compound is useful in the treatment of a disease/condition in which modulation of chemokine receptor activity is beneficial.La presente invención proporciona los compuestos de la fórmula (I). La presente invención también proporciona composiciones y combinaciones farmacéuticas que comprenden un compuesto de la fórmula (I) así como el uso de esos compuestos como inhibidores de tanquirasa y en el tratamiento de los trastornos relacionados con la señalización de Wnt y de los trastornos relacionados con la señalización de la tanquirasa 1 y 2 los cuales incluyen, pero no se limitan a, cáncer.
