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衍生物
专利权人:
LIMITED;DAIICHI SANKYO COMPANY
发明人:
KAGECHIKA, KATSUJI,影近克治,SONEDA, TSUYOSHI,曾根田刚,曾根田剛,MEGURO, MASAKI,目黑正规,目黑正規,DOI, FUMINAO,土居史尙,OGIYAMA, TOMOKO,荻山朋子,MUTO, RYO,武藤亮,KONISHI, MASAHIRO,小西正博,FURUZONO, SHIINJI,古薗信二,古
申请号:
TW102137614
公开号:
TW201422611A
申请日:
2013.10.18
申请国别(地区):
TW
年份:
2014
代理人:
摘要:
This invention relates to a compound having an exceptional blood-sugar-reducing effect or a pharmaceutically acceptable salt thereof, and more particularly to a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof, wherein X is =C(R8)-, -CH(R8)-, =N-, or -O-; Y is =C(R9)-, -CH(R9)-, or =N-; Z is =C(R10)-, -CH(R9)-, or =N-; R1 is H, a substitutable C1-3 alkyl, a substitutable C1-3 alkoxy, a substitutable C2-3 alkenyl, a substitutable C3-6 cycloalkyl, a C1-3 alkoxycarbonyl, a substitutable aminocarbonyl, a heterocyclic carbonyl, a carboxy, or a halogen; R2 is the same or different and is H, a C1-3 alkyl, a C3-6 cycloalkyl, a C1-3 alkoxy, a carboxy, or a halogen; R3 is H, a substitutable C1-3 alkyl, a C3-6 cycloalkyl, a substitutable C1-3 alkoxy, or carboxy; R4 and R5 are the same as or different from the C1-3 alkyl or are bonded to form a 3-6 membered saturated carbon ring; R6 and R7 are the same as or different from the C1-3 alkyl or are bonded to form a 3-6 membered saturated carbon ring; R8 is H or a substitutable C1-3 alkyl; R9 is H, a substitutable C1-3 alkyl, a C1-3 alkoxycarbonyl, a carboxy, or a carboxy-substituted C2-3 alkenyl; R10 is H, a C1-3 alkoxy, a substitutable C1-3 alkyl, a C6-10 aryl, a heterocyclic ring, a C1-3 alkoxycarbonyl, a substitutable aminocarbonyl, a carboxy-substituted C2-3 alkenyl, or a carboxy; n is 0-1; m is 0-1; and t is 1-2.本發明係關於具有優異之血糖降低作用的化合物或其藥理上容許鹽。一種以下述通式(I)所表示之化合物或其藥理上容許鹽,[式中,X為=C(-R8)-、-CH(-R8)-、=N-、-O-;Y為=C(-R9)-、-CH(-R9)-、=N-;Z:=C(-R10)-、-CH(-R9)-、=N-;R1為氫原子、可取代之C1-C3烷基、可取代之C1-C3烷氧基、可取代之C2-C3烯基、可取代之C3-C6環烷基、C1-C3烷氧羰基、可取代之胺基羰基氮、雜環羰基、羧基、鹵素原子;R2為相同或相異,氫原子、C1-C3烷基、C3-C6環烷基、C1-C3烷氧基、羧基、鹵素原子;R3為氫原子、可取代之C1-C3烷基、C3-C6環烷基、可取代之C1-C3烷氧基、羧基;R4及R5為相同或相異C1-C3烷基、或R4及R5鍵結而形成3-6員飽和碳環;R6及R7為相同或相異C1-C3烷基、或R6及R7鍵結而形成3-6員飽和碳環;R8為氫原子、可取代之C1-C3烷基;R9為氫原子、可取代之C1-C3烷基、C1-C3烷氧羰基、羧基、經羧基取代之C2-C3烯基;R10為氫原子、C1-C3烷氧基、可取代之C1-C3烷基、C6-C10芳基、雜環基、C1-C3烷氧羰基、可取代之胺基羰基、經羧基取代之C2-C3烯基、羧基;n為0~1;m為0~1;t為1~2]。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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