HANSEN TODD M.,KUNZER AARON R.,DING HONG,WENDT MICHAEL,MANTEI ROBERT,HASVOLD LISA,SULLIVAN GERARD,WANG LE,DOHERTY GEORGE,ELMORE STEVEN,SONG XIAOHONG,SOUERS ANDREW J.,BRUNCKO MILAN,WANG GARY T.,HEXAMER
申请号：
NZ60346310
公开号：
NZ603463A
申请日:
2010.11.22
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein. In one embodiment the compound is N-(4-{ [4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]sulfamoyl} -2-nitrophenyl)-4-cyanopiperidine-1-carboxamide.
