The present invention relates to a vaccine comprising an epitope of a heat shock protein, and a combination therapy thereof. A vaccine composition comprising a polypeptide, which is an epitope of heat shock protein 90 represented by the amino acid sequence of SEQ ID NO: 1 or 2, of the present invention, can be generally used in most patients, can be readily industrialized, and has a remarkably excellent antitumor effect, thereby being usable in economically preventing and treating cancer.
