Methods for rescuing learning, memory and/or motor function deficits associated with frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) are disclosed. The method comprises: a) administering to an animal having FTLD-U a therapeutically effective amount of an autophagy inducer； b) causing a decrease in the amount of ubiquitinated TDP-43 aggregation forms in the brain of the animal； and c) causing an improvement of the learning, memory capacities and/or motor function of the animal.
