TOOLGEN INCORPORATED;COLLEGE OF MEDICINE POCHON CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
Jae Young LEE,Seokjoong KIM,Hee Sook BAE,Jihwan SONG,Hyun Jung PARK
申请号：
US16622739
公开号：
US20200101173A1
申请日:
2018.06.14
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present specification relates to an artificial manipulation or modification in an expression regulatory gene of an over-amplified repeated sequence. More specifically, a system for regulating the expression of an over-amplified repeated sequence including an artificially manipulated gene to reduce the expression of the over-amplified repeated sequence. The artificially manipulated gene includes one or more genes selected from the group consisting of an SPT4 gene, SPT5 gene, SUPT4H gene, and SUPT5H gene. The artificially manipulated gene includes an artificial mutation in a genomic sequence of the gene. The artificially manipulated gene includes a gene whose function is impaired or has reduced expression.
