BRIAN TRAUTMAN,DIANA MANZANEDO,JASON M. PERRY,JEAN C. SUNG,WESLEY H. DEHAAN
申请号：
BR112015025160
公开号：
BR112015025160A2
申请日:
2014.03.13
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
Tiotropium Dry Powders The present invention relates to breathable dry powder comprising breathable dry particles comprising sodium chloride, leucine, and tiotropium bromide, wherein sodium chloride is about 60% to about 90%. %, leucine is from about 10% to about 40%, tiotropium bromide is from about 0.01% to about 0.5%, and optionally one or more additional therapeutic agents, up to about 20%, where all percentages are weight percentages on a dry basis and all breathable dry particle components total 100%. The invention also relates to breathable dry powders containing breathable dry particles comprising sodium chloride, leucine, and tiotropium bromide, wherein sodium chloride is from 67% to 84%, leucine is from 12% to 28%. , tiotropium bromide is from about 0.01% to about 0.5%, and optionally one or more additional therapeutic agents, up to about 20%, wherein all percentages are weight percent on a basis. dry and all breathable dry particle components total 100%. The invention also relates to breathable dry powders containing breathable dry particles comprising about 79.5% to about 80.5% (w / w) sodium chloride, about 19.5% to about 20%. , 5% (w / w) leucine, and about 0.01% to about 0.5% (w / w) tiotropium bromide, and methods for treating a subject using breathable dry powders.1/1 resumo pós secos de tiotrópio a presente invenção se refere a pó seco respirável compreendendo partículas secas respiráveis que compreendem cloreto de sódio, leucina, e brometo de tiotrópio, em que o cloreto de sódio é de cerca de 60% a cerca de 90%, a leucina é de cerca de 10% a cerca de 40%, o brometo de tiotrópio é de cerca de 0,01% a cerca de 0,5%, e, opcionalmente, um ou mais agentes terapêuticos adicionais, até cerca de 20%, em que todas as percentagens são percentagens em peso em uma base seca e todos os componentes de partículas secas respiráveis totalizam 100%. a invenção também se refere a pós secos respiráveis que contêm partículas secas respiráveis que compreendem cloreto d
