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Materials and Methods for Modulation of Tendon Healing
专利权人:
THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
发明人:
Derek Stewart GILCHRIST,Neal Lindsay MILLAR
申请号:
US15110108
公开号:
US20160333345A1
申请日:
2015.01.14
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The invention relates to the use of microRNA 29 and precursors and mimics thereof for the modulation of tendon injury and the biomechanical properties of tendon. In particular, the invention derives from the finding that synthesis of type 1 collagen in tenocytes is less sensitive to miR-29 than is synthesis of type 3 collagen, thus enabling the balance between the collagen subtypes to be modulated in favour of type 1 collagen, mitigating reduction in biomechanical properties during healing.
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