PROCEDES DE REDUCTION DE L'IMMUNOGENICITE CONTRE LE FACTEUR VIII CHEZ LES INDIVIDUS SOUMIS A UN TRAITEMENT PAR FACTEUR VIII

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专利权人:

BIOGEN IDEC MA INC.;PUGET SOUND BLOOD CENTER

发明人:

JIANG, HAIYAN,LIU, TONGYAO,KRISHNAMOORTHY, SRIRAM,JOSEPHSON, NEIL,GLENN, PIERCE

申请号：

CA2863329

公开号：

CA2863329A1

申请日:

2013.01.12

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

The present disclosure provides methods of administering chimeric and hybrid Factor VIII (FVIII) polypeptides comprising FVIII and Fc to subjects at risk of developing inhibitory FVIII immune responses, including anti-FVIII antibodies and/or cell-mediated immunity. The administration is sufficient to promote coagulation and to induce immune tolerance to FVIII. The chimeric polypeptide can comprise full-length FVIII or a FVIII polypeptide containing a deletion, e.g., a full or partial deletion of the B domain.

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中国工程科技知识中心

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http://www.ckcest.cn/home/