UNIVERSIDADE FEDERAL DE PERNAMBUCO;UNIVERSIDADE FEDERAL RURAL DE PERNAMBUCO
发明人:
JACIANA DOS SANTOS AGUIAR,LUDHIMILLA SUELEN GOMES LINS DE LIMA,MONICA FREIRE BELIAN,TERESINHA GONCALVES DA SILVA,WAGNER EDUARDO DA SILVA
申请号：
BR102017022274
公开号：
BR102017022274A2
申请日:
2017.10.17
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
The present invention is a binary platinum coordination compound, containing in its structure two platinum (nuclei) platinum with oxidation number (2 +),A two -neutral bridge binder, and three other neutral binders in each platinum centre (ii). The aforementioned compound has antineoplastic action and can be used as a cancer medicine； as well, it is characterised as a technological innovation because it has an unconventional structure compared to the platinum drugs available on the market； and also how much platinum drugs are available on the market； and Its potential for antitumoral and reduced side effects. With respect to the present invention, it was presented as a satisfactory alternative to antitumoral treatment compared to analogue, which is available on the market and contains only one platinum core (ii),Since for this last case (mononuclear complexes),The same is impossible to cause more occurrences of intertwined injury to the nDNA. The percentage of tumour inhibition obtained for this invention after conducting in vivo tests in front of the cell line used for sarcoma 180 was 49%,Thus proving his action as an antineoplastic chemotherapy； as well as exhibiting a low expression of side effects, no death occurs in the treated group when compared to the chemotherapeutic pattern available on the market.a presente invenção trata-se de um composto de coordenação binuclear de platina, contendo em sua estrutura dois centros (núcleos) de platina com número de oxidação (2+), um ligante em ponte bidentado neutro, e outros três ligantes neutros em cada centro de platina (ii). o já referido composto apresenta ação antineoplásica, podendo ser utilizado como medicamento contra o câncer； bem como, caracteriza-se como uma inovação tecnológica, pois possui estrutura não convencional, quando comparada aos fármacos de platina disponíveis no mercado； e também quanto ao seu potencial antitumoral e efeitos colaterais reduzidos. ainda com relação à presente invenção, a mesma apres
