Devices, systems, and methods for evaluating blood flow with vascular perfusion imaging are disclosed. In an embodiment, a medical system is disclosed. One embodiment of the medical system comprises a perfusion imaging system configured to obtain perfusion imaging data associated with movement of contrast through a vessel of a patient, a graphical user interface, and a medical processing unit in communication with the perfusion imaging system and the graphical user interface. The medical processing unit is configured to receive a first set of perfusion imaging data from the perfusion imaging system, determine at least one parameter representative of the movement of the contrast through the vessel of the patient, generate a first graphical representation of the first set of perfusion imaging data and the at least one parameter determined based on the first set of perfusion imaging data, and output the first graphical representation to the graphical user interface.
