Subhra Mohapatra;Eleni Markousta;Shyam S. Mohapatra
发明人:
Shyam S. Mohapatra,Subhra Mohapatra,Eleni Markousta
申请号：
US16531734
公开号：
US20200061207A1
申请日:
2019.08.05
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A multifunctional dendrimer nanoparticle and method of treating diseases of the posterior segment of the eye is presented. The functionalized polyamidoamine (PAMAM) dendrimer effectively delivers drugs and/or genes to the posterior eye, thereby providing for the effective, non-invasive, and topical treatment of diseased in the posterior eye. The multifunctional dendrimer nanoparticle has shRNA-encoding DNA and small molecule drug encapsulated cyclodextrin complexed to the outer surface of the dendrimer for delivery to the posterior segment of the eye.
