JORDAN, Allan,NEWTON, Rebecca,WASZKOWYCZ, Bohdan,SUTTON, Jonathan Mark,HYND, George,PAOLETTA, Silvia,FORDYCE, Euan Alexander Fraser
申请号:
SG11201808878U
公开号:
SG11201808878UA
申请日:
2017.04.18
申请国别(地区):
SG
年份:
2018
代理人:
摘要:
wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.