The invention provides a composition comprising nanoparticles comprising a taxane and a carrier protein for use in a method of treating a proliferative disease in an individual, wherein the method further comprises administering to the individual at least one other agent that inhibits a DNA methyltransferase. The invention further provides a kit and a medicine comprising a composition comprising nanoparticles comprising a taxane and a carrier protein, and at least one other agent that inhibits a DNA methyltransferase.
