Stannous fluoride polyol solid solutions combine three complimentary, biochemical mechanisms attributed to Sn++, F−； and Polyol, respectively to reduce growth and metabolism of Streptococcus mutans while effecting superior Bioactivity Quotients. The stannous fluoride polyol solid solution particulate compositions of the present invention comprise:(a) stannous fluoride at between about 0.01 and about 0.8% by weight；(b) a polyol at between about 0.1 and about 30% by weight；(c) an astringency neutralizer at between about 0.01 and about 0.4% by weight, where the ratio of astringency neutralizer to stannous fluoride is from between about 0.01 and about 0.2；(d) a mucoadhesive at between about 1.5 and about 70% by weight, wherein the ratio of mucoadhesive to stannous fluoride polyol is from between about 7 to 1 and about 25 to 1；(e) a pH stabilizer, selected from the group consisting of malic, fumaric, citric acid and combinations thereof, wherein the ratio of pH stabilizer to stannous fluoride polyol is from between about 0.03 and 5 and preferably from between about 0.1 and about 3； and(f) optional flavorants, stabilizers, preservatives, conditioners, and oral care adjuncts.
