The present invention provides curcumol derivatives of the following formula (I) or pharmeceutical acceptable salts thereof: wherein, Y is selected from the group consisting of =CHR 2 , -CH 2 R 2 , =O, -OH or -OR 1 ；R 1 is selected from H, R, RCO or HO 3 S； and R is selected from the group consisting of H； saturated or unsaturated linear C 1-10 hydrocarbon group and the like； R 2 is selected from the group consisting of F； Cl； Br； I； H； -OH； -OR； -HSO 3 and the like； with the proviso that both R 1 and R 2 are not H. The present invention also provides anti-tumor or antiviral pharmaceutical compositions comprising said derivatives or pharmeceutical acceptable salts thereof. The present invention further provides the use of said derivatives or pharmeceutical acceptable salts thereof in the preparation of a medicament for prophylaxis and/or treatment tumor or an antiviral medicament.
