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Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer
专利权人:
Keiji Hasumi
发明人:
Keiji Hasumi,Yoshikazu Kitano,Hideo Ohishi,Haruki Koide,Keiko Hasegawa,Ritsuko Narasaki
申请号:
US11991406
公开号:
US08110596B2
申请日:
2007.03.20
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides a triprenyl phenol compound represented by the following formula (II) and (III) and having a thrombolysis-enhancing activity, and an efficient method for producing the triprenyl phenol compound. In formula (II) and (III), R1 represents an aromatic group having as a substituent or as a part of a substituent at least one member selected from the group consisting of a carboxyl group, a hydroxyl group, a sulfonic acid group and a secondary amino group, or an aromatic group which comprises a secondary amino group and may comprise nitrogen R4 in the general formula (III) represents an aromatic amino acid residue represented by the general formula (III-1) below X represents —CHY—(CH3)2Z and Y and Z are respectively —H or —OH or together form a single bond: (III-1) wherein R5 represents a hydroxyl group which may be present or absent and n represents an integer of 0 or 1.
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