A self-setting biodegradable bioactive bone graft putty material and application thereof. The bone graft putty material comprises: a bioactive glass, a calcium sulfate hemihydrates, a tricalcium silicate, and a mixed solution. The bone graft putty material can replace the conventional inert bone cement applied in vertebroplasty surgery, knee/hip joint replacement surgery, and other bone fracture operations. This new bone cement material can set within an appropriate time to build mechanical strength gradually, enhanced bioactivity and osteoconductivity, with a slow biodegradability. It can be mixed with antibiotic solutions without affecting setting time and mechanical strength significantly.一種自固化可降解的生物活性膏劑骨修復材料及應用,骨修復材料包括生物活性玻璃、半水硫酸鈣、矽酸三鈣和調和液,替代常用的惰性骨水泥而用於骨科椎體成型、膝髖關節置換以及其它骨折手術。能在合理的時間內凝固建立起力學強度,增強生物活性及骨傳導性和緩慢降解。可直接與抗菌素液體調和,對凝固時間和力學強度無明顯影響。