A method of treating various diseases, including performing ear anesthesia of various cranial nerves. A pharmaceutical composition is administered to the ear canal of a subject in need of such treatment, the composition comprising an analgesic and / or at least one anesthetic. Compositions useful in the disclosed methods are also provided.様々な脳神経の耳麻酔を行うことを含む様々な疾患の治療方法。医薬組成物をかかる治療を必要とする対象の外耳道に投与し、該組成物は鎮痛剤及び/または少なくとも1つの麻酔剤を含む。本開示の方法に有用な組成物もまた提供する。