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20-HETE RECEPTOR (GPR75) ANTAGONISTS AND METHODS OF USE
专利权人:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;New York Medical College
发明人:
John R. Falck,Miehal L. Schwartzman,Victor Garcia
申请号:
US16083404
公开号:
US20200030291A1
申请日:
2017.03.08
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention concerns compounds and their use to treat cardiovascular disease, renal disease, thrombic disease, stroke, metabolic syndrome, cell proliferation, and ischemic cardiovascular disorders. Compounds of the present invention display significant potency as antagonists of 20-hydroxyeicosatetraenoic acid (20-HETE), and function as anti-hypertensive, anti-inflammatory, or anti-growth agents.
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