PROBLEM TO BE SOLVED: To provide a medicine for the prevention and treatment of diabetes mellitus, diseases associated with diabetes mellitus, or diabetic complication, without developing side effects.SOLUTION: The invention provides a medicine in which (A) 1-thio-D-glucitol compound represented by formula (I), and (B) one or more kind selected from a biguanide agent, an insulin secretagogue, an insulin sensitivity enhancing agent, insulin, a dipeptidyl-peptidase-IV inhibitor, an α-glucosidase inhibitor, and GLP-1 agonist are combined.SELECTED DRAWING: None【課題】副作用が見られない、糖尿病、糖尿病関連疾患または糖尿病合併症の予防および治療のための、医薬の提供。【解決手段】（Ａ）式（Ｉ）で表される１－チオ－Ｄ－グルシトール化合物と、（Ｂ）ビグアナイド薬、インスリン分泌促進薬、インスリン感受性増強薬、インスリン、ジペプチジルペプチダーゼＩＶ阻害剤、α－グルコシダーゼ阻害剤およびＧＬＰ－１作動薬から選ばれる１種以上と、を組み合わせてなる医薬。【選択図】なし
