MODULATION DE L'IMMUNOGENICITE DE FVIII PAR VWF TRONQUE

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专利权人:

CSL BEHRING LENGNAU AG

发明人:

VERHAGEN, ANNE,PESTEL, SABINE,WEIMER, THOMAS,HOFMANN, MARCO,HUYNH, HUY,MARASKOVSKY, EUGENE

申请号：

CA3068098

公开号：

CA3068098A1

申请日:

2018.06.22

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present invention relates to a recombinant polypeptide comprising a truncated von Willebrand Factor (VWF) capable of binding to blood coagulation Factor VIII (FVIII) for use in reducing the immunogenicity of Factor VIII (FVIII) wherein said recombinant polypeptide and a blood coagulation Factor VIII (FVIII) protein are co-administered to a subject suffering from a 10 blood coagulation disorder. The invention further relates to pharmaceutical compositions and kits for said use.

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