James Andrew Huntington,Stéphanie Polderdijk,Trevor Baglin
申请号：
US15103420
公开号：
US09982035B2
申请日:
2014.12.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
This invention relates pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1′ residues within the reactive center loop (RCL) to display increased specificity for anticoagulant proteases. These modified serpin molecules may be useful in therapy, for example as pro-coagulants for the treatment of bleeding.
